Turmeric Regulates Angiogenesis in Metabolic Syndrome

Blood Vessels

Growth of new blood vessels is a process called angiogenesis. When it works properly, angiogenesis helps with tissue growth and repair.  (vii.17)

But angiogenesis promotes disease in an unhealthy environment of chronic inflammation - such as in metabolic syndrome. These conditions include:  (vii.2, 17)

Growth factors are proteins our cells (including fat cells) produce that stimulate angiogenesis. Doctors prescribe drugs that target and reduce abnormally high levels of growth factors to help treat certain kinds of tumors and age-related macular degeneration.  (vii.17)

A number of natural plant compounds, including those found in turmeric, inhibit out-of-control growth factors. Some of turmeric's compounds also help regulate leptin levels, a hormone involved in angiogenesis.  (vii.17)

Table VII.1: Turmeric Compounds Inhibit Growth Factors in Metabolic Syndrome (vii.202529)
Turmeric Compounds Effect
↓ VEGF ↓ IGF-1
Alpha-linolenic acid  (vii.18-19)  
Caffeic acid  (vii.20-21)  
Curcumin  (vii.1, 10, 21-22)
Eugenol  (vii.19, 23)  
Limonene  (vii.20, 24)  
Myricetin  (vii.25-26)  
Quercetin  (vii.21, 25)  
Resveratrol  (vii.27-28)
Vitamin C  (vii.29-30)  
Metabolic Syndrome Diseases Involved
Why Is This Important?
  • Growth factors help develop new blood vessels—a process called angiogenesis.  (vii.10)
  • Angiogenesis is necessary for expansion of body fat and obesity.  (vii.10)
  • VEGF is the main growth factor that stimulates angiogenesis. Abnormal or unhealthy levels of VEGF promote the angiogenesis involved in diseases such as retinopathy, cancer, and atherosclerosis.  (vii.21, 31)
  • High levels of another growth factor, IGF-1, contribute to insulin resistance and angiogenesis.  (vii.32)
Vascular endothelial growth factor.  (vii.10)
Insulin-like growth factor-1.  (vii.21)
Technically called adipose tissue.  (vii.10)

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