Cytokines

Turmeric and turmeric compounds help regulate cytokines in cells.
Table III.2: Cytokines
WHAT ARE CYTOKINES?

Why are cytokines produced?

Cytokines are small proteins that almost all cells (especially epithelial and endothelial cells) can produce in response to some stimulus. Injured, infected, or diseased tissue cells secrete chemokine types of cytokines. (iii.5-632-36)

Pro-inflammatory cytokines are crucial to the immune system response. When properly regulated, they help the body recover. (iii.53133-3437-39)

What do they do?

Cytokines act as signaling molecules between cells. They help organize the immune system response to anything that knocks the body out of balance - including wounds, chemical toxins, microbes, heart attacks, and even disease conditions such as those found in cancer and brain disorders(iii.5-632-35)

Chemokines are also cytokines but have a different function. They act as signaling beacons so that immune system cells (such as neutrophils) can locate and help the cells that need them. (iii.5-632-36)

What happens if cytokines are unregulated?

When the immune system response becomes dysfunctional, over-production of cytokines contributes to disease development and progression. Chronic inflammation and diseases associated with unhealthy inflammatory responses leads to even more unregulated cytokine production. (iii.53133-3437-39)

Cytokines can also interfere with therapy for a disease, making the treatment less effective (e.g. radiation therapy for cancer). (iii.53133-3437-39)

EFFECTS OF TURMERIC AND TURMERIC COMPOUNDS

Research indicates that the turmeric compound curcumin helps regulate cytokine production. Lab, animal, and human studies show it blocks the abnormal production of cytokines. This could help prevent or treat the conditions both caused and associated with chronic inflammation. Some of these include: (iii.1)

Tissue of varying number of layers that covers all internal and external body surface. (iii.35)
Lining of capillaries and arteries. (iii.35)

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