Dysfunctional Immune System Contributes to Alzheimer's Disease

Turmeric compounds can help promote the immune system's ability to get rid of amyloid proteins before they form plaques in the brain.

The immune system has an efficient mechanism called phagocytosis to dispose of waste products in the body. This includes getting rid of Aβ protein fragments that form the clumps and tangled neurons that kill brain cells. Macrophage-type immune system cells are white blood cells. One of their functions is to engulf pathogens and cellular debris and safely dispose of them. (iv.59)

Figure IV.8: Phagocytosis Clears out AΒ Proteins in Brain

Figure IV.8: Phagocytosis Clears out AΒ Proteins in Brain

But this waste disposal system barely works in Alzheimer's disease patients: (iv.59)

Figure IV.9: Impaired Immune-Phagocytosis System in Alzheimer's Disease

Figure IV.9: Impaired Immune-Phagocytosis System in Alzheimer's Disease

Dysfunctional phagocytosis is due to suppressed gene expression for some key proteins involved in the process. (iv.59)


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